Thank you for this information. As an insulin diabetic I have often wondered if there may be some connection. Your article is extremely helpful. Understanding some contributors to lipedema is great knowledge. I have had a conversation with my endocrinologist she was not aware of a connection. I gave her some information that I received from Lipedema Australia and she was happy with that. I also have connective tissue disorder so when I go to my appointment tomorrow, I will give them the same information as I have told them years ago about my lipedema. Your research and knowledge is amazing. Thank you and keep up the great work you give us inspiration.
Thanks for restacking and commenting, Karen! 💛 And thank you for sharing this with me. This kind of feedback helps me create more valuable content for all of us in the future 🙏
TGLUT Translocation GLUT-4 and -12 together can have 10X capacity of other 11 glucose transporters combined. Designed as a gated response on eating, must these protein receptors must physically move to surface for receipt of glucose from glucose-insulin carrier in blood. If not at surface, no pickup (think short order cook at pickup window). If not received into cells for energy burning, pancreas signals for more insulin already not the problem causing excess glucose to be stored as fat and inhibiting fat burning. The 10 year insulin resistance cycle from post-parandial high glucose through pre-diabetic to diabetic. Missed by most endocrinologists by failure to test fasting insulin which can suppress glucose into normal range. Insulin resistance calculation HOMa-IR calculation (safer than clinical glucose tolerance test), inputs fasting glucose and fasting insulin. Lymphatic disorders more challenging for this uptake and increased insulin sensitivity due to larger limbs and fibrosis, leaky lymph forming glycoaminoglycans. The latter useful for fascia structure but lymph no long fluid and in exit channel causing eventual progression and fibrosis (reversible with a lot of work). Easier the earlier detection as is insulin resistance.
Thank you for this information. As an insulin diabetic I have often wondered if there may be some connection. Your article is extremely helpful. Understanding some contributors to lipedema is great knowledge. I have had a conversation with my endocrinologist she was not aware of a connection. I gave her some information that I received from Lipedema Australia and she was happy with that. I also have connective tissue disorder so when I go to my appointment tomorrow, I will give them the same information as I have told them years ago about my lipedema. Your research and knowledge is amazing. Thank you and keep up the great work you give us inspiration.
Thanks for restacking and commenting, Karen! 💛 And thank you for sharing this with me. This kind of feedback helps me create more valuable content for all of us in the future 🙏
TGLUT Translocation GLUT-4 and -12 together can have 10X capacity of other 11 glucose transporters combined. Designed as a gated response on eating, must these protein receptors must physically move to surface for receipt of glucose from glucose-insulin carrier in blood. If not at surface, no pickup (think short order cook at pickup window). If not received into cells for energy burning, pancreas signals for more insulin already not the problem causing excess glucose to be stored as fat and inhibiting fat burning. The 10 year insulin resistance cycle from post-parandial high glucose through pre-diabetic to diabetic. Missed by most endocrinologists by failure to test fasting insulin which can suppress glucose into normal range. Insulin resistance calculation HOMa-IR calculation (safer than clinical glucose tolerance test), inputs fasting glucose and fasting insulin. Lymphatic disorders more challenging for this uptake and increased insulin sensitivity due to larger limbs and fibrosis, leaky lymph forming glycoaminoglycans. The latter useful for fascia structure but lymph no long fluid and in exit channel causing eventual progression and fibrosis (reversible with a lot of work). Easier the earlier detection as is insulin resistance.