GLP-1 is a natural gut hormone that helps control appetite, blood sugar, and how fast the stomach empties. Medicines that stimulate the GLP-1 receptor (like exenatide, semaglutide, tirzepatide has GLP-1 plus GIP) are already used for diabetes and weight management. Many women with lipedema also live with insulin resistance and weight gain, so it’s fair to ask: can GLP-1 biology help with lipedema symptoms—not just the scale?
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